Ii-injini ze-645 zangena kwimveliso ngo-1965. Njengoko uchungechunge lwe-567 lufikelele kwimida yalo ekunyuseni kwamandla ehashe, kufuneka ukufuduka okukhulu; oku kuphunyezwe ngokunyusa ibhore ukusuka kwi-8+1⁄2 kwi-(216 mm) kuthotho lwe-567 ukuya kwi-9+1⁄16 kwi-(230 mm) kuluhlu lwe-645, ngelixa igcina i-stroke efanayo kunye nokuphakama kwedekhi. Ngelixa i-crankcase yalungiswa ukusuka kuthotho lwe-567, i-567C kunye neenjini zamva (okanye ii-injini ezingama-567 eziguqulelwe kwiinkcukacha ze-567C, ngamanye amaxesha zibizwa ngokuba zii-injini ze-567AC okanye ii-567BC) zingamkela iinxalenye zenkonzo ezingama-645, ezifana neendibano zamandla. Ngokwahlukileyo, i-injini ye-567E isebenzisa ibhloko ye-645E yochungechunge kunye neendibano zamandla ze-567.

Zonke ii-injini ezingama-645 zisebenzisa i-Roots blower okanye i-turbocharger ukurhabula isilinda. Kwii-injini ze-turbocharged, i-turbocharger iqhutywa ngegiya kwaye ine-clutch ebalekayo eyivumela ukuba isebenze njenge-centrifugal blower ngesantya esisezantsi se-injini (xa igesi ephumayo kunye neqondo lobushushu lilodwa lingonelanga ukuqhuba i-iturbine) kunye ne-turbocharger eqhutywa yi-exhaust. ngesantya esiphezulu. I-turbocharger inokubuyela ekusebenzeni njenge-supercharger ngexesha leemfuno zokunyuka okukhulu kwamandla emveliso ye-injini. Ngelixa kubiza kakhulu ukugcina kune-Roots blowers, ibango le-EMD yokuba olu yilo luvumela "kakhulu" ukunciphisa ukusetyenziswa kwamafutha kunye nokukhutshwa, ukuphuculwa kokusebenza komgangatho ophakamileyo, kunye nokuya kuthi ga kwi-50 yepesenti yokunyuka kwamandla aphezulu ehashe ngaphezu kweenjini ezivuthelwa yiRoots ngokufanayo. ukususwa kwe-injini.